A multimodal approach to discomfort management may well enhance the treatment method of Continual agony, along with support With all the thriving tapering with the opioid analgesic (see WARNINGS, Withdrawal and DRUG ABUSE AND DEPENDENCE).
Stay clear of providing acetaminophen and codeine phosphate tablets to little ones among 12 to eighteen decades of age that have hazard variables for respiratory complications for instance obstructive slumber apnea, being overweight, or underlying lung challenges.
The concomitant use of acetaminophen and codeine phosphate tablets with all cytochrome P450 2D6 inhibitors (e.g., amiodarone, quinidine) may well cause a rise in codeine plasma concentrations as well as a minimize in active metabolite morphine plasma focus which could lead to an analgesic efficacy reduction or indications of opioid withdrawal.
Ask your physician or pharmacist if you ought to have naloxone available to address opioid overdose. Instruct All your family members or domestic users concerning the signs of an opioid overdose and how to treat it.
Will not abruptly discontinue acetaminophen and codeine phosphate tablets within a patient bodily depending on opioids. When discontinuing acetaminophen and codeine phosphate tablets within a physically dependent affected individual, steadily taper the dosage.
If it is necessary to switch from An additional opioid to codeine, a conservative tactic is suggested as it can be most secure to undervalue the codeine dose than to overestimate and manage an adverse reaction on account of overdose.
Look at the labels on your medicines to more info check out should they comprise acetaminophen, and inquire your pharmacist If you're Not sure.
In sufferers who might be at risk of the intracranial effects of CO2 retention (e.g., People with evidence of check here improved intracranial tension or Mind tumors), acetaminophen and codeine phosphate Codeine Phosphate 30mg tablets may perhaps minimize respiratory travel, and also the resultant more info CO2 retention can further boost intracranial strain.
The danger for significant respiration challenges is higher when you start this medication and following a dose raise, or if you are taking the wrong dose/strength. Using this medication with Liquor or other medicines that can result in drowsiness or respiration problems might cause extremely really serious side effects, including death. Also, other medicines can impact the elimination of codeine from the entire body, which may have an effect on how codeine operates.
Just like Grownups, when prescribing codeine for adolescents, healthcare vendors need to pick the cheapest effective dose for that shortest time frame and advise people and caregivers about these pitfalls and the indications of morphine overdose (see OVERDOSAGE).
The majority of the circumstances of liver injuries are affiliated with the use of acetaminophen at doses that exceed 4,000 milligrams a day, and infrequently contain more than one acetaminophen-containing product (see WARNINGS).
Watch these types of patients for signs of sedation and respiratory melancholy, especially when initiating therapy with acetaminophen and codeine phosphate tablets.
•Retail store Acetaminophen and Codeine Phosphate Tablets, USP securely, from sight and attain of children, and in a place not accessible by Many others, which include website visitors to the home.
Inform people that acetaminophen and codeine phosphate tablets could impair the psychological and/or physical qualities necessary for that overall performance of doubtless hazardous duties here like driving an auto or functioning equipment and to stay away from this sort of responsibilities even though having this item, until eventually they know how they are going to respond for the medication.